To View Our Prices For Zyban Click Here Chemical Name: BUPROPION Common uses This medicine is a smoking cessation aid used to help you stop smoking.

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Wednesday, 9 February 2011

Does Zyban Really Work?

WARNINGS
Patients should be made aware that ZYBAN contains the same active ingredient found
in WELLBUTRIN and WELLBUTRIN SR used to treat depression, and that ZYBAN
should not be used in combination with WELLBUTRIN, WELLBUTRIN SR, or any other
medications that contain bupropion.
Because the use of bupropion is associated with a dose-dependent risk of seizures,
clinicians should not prescribe doses over 300 mg/day for smoking cessation. The risk of
seizures is also related to patient factors, clinical situation, and concurrent medications,
which must be considered in selection of patients for therapy with ZYBAN. ZYBAN should
be discontinued and not restarted in patients who experience a seizure while on treatment.
• Dose: For smoking cessation, doses above 300 mg/day should not be used. The seizure
rate associated with doses of sustained-release bupropion up to 300 mg/day is
approximately 0.1% (1/1,000). This incidence was prospectively determined during an
8-week treatment exposure in approximately 3,100 depressed patients. Data for the
immediate-release formulation of bupropion revealed a seizure incidence of
approximately 0.4% (4/1,000) in depressed patients treated at doses in a range of 300 to
450 mg/day. In addition, the estimated seizure incidence increases almost tenfold
between 450 and 600 mg/day.
• Patient factors: Predisposing factors that may increase the risk of seizure with
bupropion use include history of head trauma or prior seizure, central nervous system
(CNS) tumor, the presence of severe hepatic cirrhosis, and concomitant medications
that lower seizure threshold.
• Clinical situations: Circumstances associated with an increased seizure risk include,
among others, excessive use of alcohol or sedatives (including benzodiazepines);
addiction to opiates, cocaine, or stimulants; use of over-the-counter stimulants and
anorectics; and diabetes treated with oral hypoglycemics or insulin.
• Concomitant medications: Many medications (e.g., antipsychotics, antidepressants,
theophylline, systemic steroids) are known to lower seizure threshold.
Recommendations for Reducing the Risk of Seizure: Retrospective analysis of clinical
experience gained during the development of bupropion suggests that the risk of seizure
may be minimized if
• the total daily dose of ZYBAN does not exceed 300 mg (the maximum recommended
dose for smoking cessation), and
• the recommended daily dose for most patients (300 mg/day) is administered in divided
doses (150 mg twice daily).
• No single dose should exceed 150 mg to avoid high peak concentrations of bupropion
and/or its metabolites.
ZYBAN should be administered with extreme caution to patients with a history of
seizure, cranial trauma, or other predisposition(s) toward seizure, or patients treated with
other agents (e.g., antipsychotics, antidepressants, theophylline, systemic steroids, etc.) that
lower seizure threshold.
Hepatic Impairment: ZYBAN should be used with extreme caution in patients with severe
hepatic cirrhosis. In these patients a reduced frequency of dosing is required, as peak
bupropion levels are substantially increased and accumulation is likely to occur in such
patients to a greater extent than usual. The dose should not exceed 150 mg every other day
in these patients (see CLINICAL PHARMACOLOGY, PRECAUTIONS, and DOSAGE
AND ADMINISTRATION).

Facts about Zyban and Smoking

Zyban is a prescription medication designed to help smokers quit more easily than without the drug. It comes in a pill form. It does not contain nicotine

Zyban's history is interesting. Smokers who happened to be users of the anti-depression medication Wellbutrin (bupropion hydrochloride) often reported a lessening in the desire for cigarettes. Through further testing, the drug was found to be effective in treating the smoking addiction, and helping smokers quit. GlaxoSmithKline "repackaged" Wellbutrin and marketed it as the smoking-cessation drug Zyban.

Unlike nicotine patches or nicotine gum, Zyban does not put more nicotine into your body. If you use the patches or gum, you should stop smoking so that you don't "overdose" on nicotine. With Zyban, you continue to smoke when you first start taking the medication, eventually reaching a quit-date, and taking the drug for a period of time after quitting.

Before taking Zyban, smokers want to know what Zyban will do to make quitting easier. According to the results reported during clinical trials, "treatment with ZYBAN reduced withdrawal symptoms compared to placebo. Reductions on the following withdrawal symptoms were most pronounced: irritability, frustration, or anger; anxiety; difficulty concentrating; restlessness; and depressed mood or negative affect. Depending on the study and the measure used, treatment with ZYBAN showed evidence of reduction in craving for cigarettes or urge to smoke compared to placebo."

Zyban is not without side-effects. According the the Zyban website, "The most common side effects experienced with ZYBAN include dry mouth and difficulty sleeping. There are other risks associated with the use of ZYBAN, so it is important to talk to your healthcare professional to see whether ZYBAN is right for you. There is a risk of seizure associated with ZYBAN, which is increased in certain patients."

Zyban has proven more effective than placebo in clinical testing, with success rates ranging as high as 58% in one study. Most studies showed success rates at somewhere between 15%-25%. Long-term success rates are obviously on the lower end, as smokers tend to relapse after longer periods of time. Some studies included using Zyban in conjunction with nicotine patches.

Because medications such as Zyban have potential dangers and side-effects, the full text from the Zyban web-site quoted here:

Friday, 4 February 2011

Stop Smoking Drug Zyban Facts

Smoking addiction is an extremely bad habit to break. During the years, many therapies are developed to aid people to quit smoking. One of the them is the nicotine replacement therapy which is consist of nicotine patches, gums or even sprays. The products releases a supply of nicotine to the bloodstream.

There is another therapy and approach is becoming more popular amongst people which is the use of the drug Zyban also known as bupropion hydrochloride.

The development of Zyban as a therapy to aid quit smoking was an accident. The drug was originally design as an anti-depressant drug. During the trial of the drugs, there were many smokers who participated. It was found that those smokers have lost total interest in smoking and it was easy to quit. Thus in 1997, it was approved by the FDA as an effective quit smoking therapy and aid.

Zyban does not work the same way as nicotine replacement therapies. It does not release any nicotine. Zyban works by altering brain chemistry and as a result, cigarettes become unappealing and the desire to smoke is not there anymore.

Zyban is consumed over a period of weeks before one can stop smoking. It will take time to work like all anti-depressants. If all goes well in consuming Zyban, the process of quitting smoking would be much easier.

It is crucial to keep in mind that Zyban is also a drug. It alters brain chemistry, and even researchers are not 100 percent sure of how it works, except the fact that it was effective for many people. If you wish to resort to Zyban, please consult a doctor beforehand and note that not to take it with a mixture of other drugs because the outcome may be unknown and may lead to a disaster.

Zyban does have side effects such as dizziness, and dry mouth, even seizures in less common cases. Let your doctor know about your medical history and your lifestyle. Conditions such as whether you consumes alcohol or whether you are other drug prescription is important.

Quitting Smoking With Zyban

If you're looking for a way to quit smoking that has a proven success rate, you may be interested in a drug called Zyban. The main active ingredient of Zyban is bupropion hydrochloride, which is also known as Wellbutrin. Originally prescribed as an antidepressant, Wellbutrin exhibited a side effect of making patients lose interest in cigarettes. With the Wellbutrin results as a guide, Zyban was developed and has been available as a smoking treatment since 1998.

How Zyban Works

The reason Zyban is so effective is not clearly understood. It makes patients feel energized and gives them a sense of well-being, which makes it useful for helping people quit smoking.

Patients start taking Zyban while they are still smoking. The quit date is set for 7 days later, and the drug is continued for another 7 to 10 weeks after that quit date. Patients report minimal symptoms of nicotine withdrawal. Studies have shown that success rates of Zyban are about twice that of placebos.

If the smoker hasn't made significant improvements in his smoking habits by 10 weeks, it is unlikely that continued use of Zyban will help. Zyban treatment is like any other method for quitting smoking: in order to be effective the desire to quit has to come from within. Those who really don't want to stop smoking will find ways to sabotage any quitting plan.

The most commonly reported side effects are insomnia and a dry mouth. People with a history of seizures, eating disorders, or cirrhosis of the liver should not take it.

Compared with Patches

1 of the most popular alternatives for nicotine withdrawal is the nicotine patch -- a square patch that sticks to the skin and releases small doses of nicotine throughout the day. Patches allow the body to get the nicotine it craves without suffering the ill effects of smoking. People using patches may still feel the desire to smoke in certain situations because of associations with smoking that have nothing to do with nicotine. For example, some people associate smoking with going to a nightclub.

Patches are available in various strengths, so they can be used to wean the body gradually from its nicotine dependence. Those with a strong desire to quit smoking may find that nicotine substitutes free them to concentrate on the behavioral changes needed to rid themselves of dependency on tobacco.

Zyban does not provide nicotine to the body, it provides the smoker a feeling of well-being that allows him to give up the habit with relatively little difficulty. However, once Zyban treatment stops, the desire to smoke in certain situations may return.

Side Effects Of Patches

Patches can help eliminate the cravings associated with smoking, but they have to be used with some care. They can be worn throughout the day, but should be removed at night. Otherwise, they may cause insomnia or strange dreams.

The skin where the patch is applied may become red and itchy. These symptoms usually disappear within an hour after the patch is removed, but can cause discomfort during the day.

Both Zyban and nicotine substitutes are more effective when used in conjunction with some kind of counseling. A smoker must defeat both nicotine addiction and a series of smoking habits in order to ultimately join the ranks of the non-smoker.

Zyban Is Effective For Quitting Smoking Cigarettes

The drug zyban was originated as a cure for the problem of depression, but in recent times it was shown to have some characteristics that helped those addicted to cigarette to quit easily. By this discovery, Zyban became a popular way to quit smoking. It functions in a simple way by activating the chemical hormones in the brain, bringing about an anti - depression feeling. It completely eradicates all the feelings of withdrawal that the smoker will feel when he/she stops smoking. Zyban is an excellent way to quit smoking.

Before using the zyban therapy to quit smoking you will need to get a doctor to prescribe the drug for you and with that you can start the treatment. When you have the drug available, you will have to begin a six day treatment period for the first phase of the treatment in this first phase you are to take only one tablet of zyban every day. The second phase begins on the seventh day with you taking two tablets of zyban twice daily. On the eight day of this treatment, the patient should permanently stop smoking and continue taking the tablets as prescribed until the end of the eight week. By this time he/she would have been able to quit smoking.

There is an important fact to be pointed out: the Zyban quit smoking therapy only helps the patient deal with the physical part of the addiction which is the addiction to nicotine and the withdrawal symptoms experienced as a result of quitting nicotine. Since the cigarette addiction is twofold - the physical and psychological addiction, the psychological part of the addiction is left out of this therapy.

So, for a person to totally quit smoking using Zyban, the psychological addiction to smoking has to be dealt with by the smoker's determination to quit the habit; if not, the zyban therapy will not work without the addicts decision to quit and never return. It is hence prescribed that the psychological addiction of smokers to cigarettes should to tackled first, before the administration of the Zyban therapy or they can be done at the same time, since the Zyban treatment is for about 8 - 12 weeks. The will to quit smoking is the greatest way to start, if not, it will just be another waste of time and resources.